Convection Process Provides Medical Device Advantages Not Previously Possible
Wilson Wolf created a paradigm shift with its cell culture design disrupting age-old beliefs regarding cell production. Minnesota Rubber and Plastics (MR&P) facilitated the unique design with an efficient, high quality molded, assembled and packaged G-Rex branded product ready for the medical marketplace.
The ideal G-Rex final product assembly design was accomplished through DFM (Design For Manufacturing) collaboration with the Wilson Wolf engineers and MR&P engineers. And together, the group effort eliminated several components, and improved the overall design and final product cost. The G-Rex 100 Series set the stage for a complete line cell culture products.
Key to the G-Rex gas permeable cell culture process is the gas permeable membrane molded by Minnesota Rubber and Plastics.
In the device, the gas permeable membrane provides convection nutrient transport (not diffusion) generating the most cell cultures in the least amount of space. Convection is the key to achieving maximum cell growth with uninterrupted access to nutrients. When compared to age-old diffusion processes, Wilson Wolfs design provides the easiest and fastest way to generate the most cells in the least amount of space. It can turn 300 million cells into 100 billion cells in just 11 days. G-Rex is a patented FDA registered Class 1 medical device.
The G-Rex gas permeable membrane is contained in a 4 component thermoplastic assembly consisting of an incubator shelf, a high nutrient capacity bottle, supported by a ring at the base and a cap at the top. All molding, assembly and packaging operations are done in Minnesota Rubber and Plastics ISO 13485 Class 7 and 8 clean rooms.
Explaining its operation, Wilson Wolf officials described G-Rex process begins by adding cells and a large volume of media into the device. The incubator is set in Oxygen from ambient air and CO2 from the media is exchanged through the Gas Permeable Membrane. Cells obtain oxygen and nutrients on demand (no need for media exchange, shaking or rolling). The cultured cells are collected by withdrawing 90 percent of the media volume and removing the cells.
According to Wilson Wolf officials, the G-Rex proprietary yet straight-forward technology leads to powerful therapies. The product is now available to the medical community in multiple sizes and packaged quantities.